Ammonia → 5-(4-Chlorophenyl)-3-(5-fluoropyridin-3-yl)isoxazole

HRID 390463

반응식

HRID 390463 반응식
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]#[CH:20])=[CH:15][CH:14]=1.N>>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:9][N:8]=[C:7]([C:6]3[CH:5]=[N:4][CH:3]=[C:2]([F:1])[CH:11]=3)[CH:20]=2)=[CH:15][CH:14]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 70118Benzene, 1-chloro-4-ethynyl-HCID 866368465-Fluoro-N-hydroxynicotinimidoyl chloride

생성물 1

HCID 445462895-(4-Chlorophenyl)-3-(5-fluoropyridin-3-yl)isoxazole

실험 절차

The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 1-chloro-4-ethynylbenzene (Aldrich, 68 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.42 (s, 1H), 7.57 (dt, J=8.9, 2.3 Hz, 2H), 7.92 (dt, J=8.9, 2.3 Hz, 2H), 8.17 (ddd, J=9.3, 2.8, 1.8 Hz, 1H), 8.61 (d, J=2.8 Hz, 1H), 8.96 (t, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 277 (M+H)+, 275 (M+H)+.

출처 및 근거

ORD 기록
ord-f7526ed04c36441ea52d33ca84ba2d16
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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