Ammonia → HCID 44546352, 화합물

HRID 390470

반응식

HRID 390470 반응식
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[C:12]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([CH3:21])[CH:15]=1)#[CH:13].N>>[F:20][C:17]1[CH:18]=[CH:19][C:14]([C:12]2[O:9][N:8]=[C:7]([C:6]3[CH:5]=[N:4][CH:3]=[C:2]([F:1])[CH:11]=3)[CH:13]=2)=[CH:15][C:16]=1[CH3:21]

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 162137974-Ethynyl-1-fluoro-2-methylbenzeneHCID 866368465-Fluoro-N-hydroxynicotinimidoyl chloride

생성물 1

HCID 44546352HCID 44546352, 화합물

실험 절차

The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 4-ethynyl-1-fluoro-2-methylbenzene (Aldrich, 67 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 2.37 (d, J=2.0 Hz, 3H), 7.21 (t, J=8.9 Hz, 1H), 7.33 (s, 1H), 7.73-7.80 (m, 1H), 7.83 (dd, J=6.6, 1.9 Hz, 1H), 8.16 (ddd, J=9.2, 2.7, 1.7 Hz, 1H), 8.60 (d, J=2.7 Hz, 1H), 8.96 (t, J=1.5 Hz, 1 H) ppm; MS (DCI/NH3) m/z 273 (M+H)+.

출처 및 근거

ORD 기록
ord-806fa3256c8743e797ff71179939f8b8
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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