Ammonia → HCID 44546485, 화합물

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[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:5]=[N:6][CH:7]=[N:8][CH:9]=1.[F:11][CH:12]([F:22])[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[CH:21])[CH:15]=1.N>>[F:11][CH:12]([F:22])[O:13][C:14]1[CH:15]=[C:16]([C:20]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[N:8][CH:9]=3)[CH:21]=2)[CH:17]=[CH:18][CH:19]=1

참가 물질

반응물 3

HCID 222Ammonia

HCID 27784951-(Difluoromethoxy)-3-ethynylbenzene

HCID 86636847N-Hydroxypyrimidine-5-carbimidoyl chloride

생성물 1

HCID 44546485HCID 44546485, 화합물

실험 절차

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1-(difluoromethoxy)-3-ethynylbenzene (Fluorochemicals, 84 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.33-7.46 (m, 2H), 7.56-7.74 (m, 2H), 7.81 (dt, J=7.9, 1.1 Hz, 1H), 7.87 (s, 1H), 9.33 (s, 2H), 9.35 (s, 1H) ppm; MS (DCI/NH3) m/z 290 (M+H)+.

출처 및 근거

ORD 기록: ord-c1cfbc9ec0654c67aba007769d53ff01
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08383658B2

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