Ammonia → 3-Chloro-5-(3-(pyridin-3-yl)isoxazol-5-yl)benzonitrile

HRID 390499노트

반응식

HRID 390499 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[Cl:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([C:20]#[CH:21])[CH:19]=1)[C:15]#[N:16].N>>[Cl:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([C:20]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[CH:21]=2)[CH:19]=1)[C:15]#[N:16]

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chlorideHCID 866368483-Chloro-5-ethynylbenzonitrile

생성물 1

HCID 445465463-Chloro-5-(3-(pyridin-3-yl)isoxazol-5-yl)benzonitrile

실험 절차

The titled compound was prepared according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and the product of Example 66A (82 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.62 (ddd, J=8.0, 4.9, 0.7 Hz, 1H), 7.97 (s, 1H), 8.24 (dd, J=2.0, 1.4 Hz, 1H), 8.28 (dt, J=8.1, 1.9 Hz, 1H), 8.34 (t, J=1.7 Hz, 1H), 8.41 (t, J=1.4 Hz, 1H), 8.75 (dd, J=4.7, 1.7 Hz, 1H), 9.09 (d, J=1.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 282 (M+H)+, 284 (M+H)+.

출처 및 근거

ORD 기록
ord-97460a00d7c24a0489f610a89f4ec6dc
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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