Ammonia → 2-Fluoro-5-(3-(pyridin-3-yl)isoxazol-5-yl)benzonitrile

HRID 390500노트

반응식

HRID 390500 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([C:13]1[CH:14]=[CH:15][C:16]([F:21])=[C:17]([CH:20]=1)[C:18]#[N:19])#[CH:12].N>>[F:21][C:16]1[CH:15]=[CH:14][C:13]([C:11]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[CH:12]=2)=[CH:20][C:17]=1[C:18]#[N:19]

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chlorideHCID 534292955-Ethynyl-2-fluorobenzonitrile

생성물 1

HCID 445465472-Fluoro-5-(3-(pyridin-3-yl)isoxazol-5-yl)benzonitrile

실험 절차

The titled compound was prepared according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and the product of Example 68A (73 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.49 (s, 1H), 7.52-7.68 (m, 2H), 8.28 (ddd, J=8.8, 5.1, 2.4 Hz, 1H), 8.33-8.41 (m, 2H), 8.68 (dd, J=4.9, 1.5 Hz, 1H), 9.09 (d, J=2.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 266 (M+H)+.

출처 및 근거

ORD 기록
ord-8dddfa36a97348dfb12af912ab9649d1
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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