Ammonia → 3-(5-Chloropyridin-3-yl)-5-(3,4-difluorophenyl)isoxazole

반응식

[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[C:12]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=1)#[CH:13].N>>[Cl:1][C:2]1[CH:11]=[C:6]([C:7]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=3)[O:9][N:8]=2)[CH:5]=[N:4][CH:3]=1

참가 물질

반응물 3

HCID 222Ammonia

HCID 138784543,4-Difluorophenylacetylene

HCID 866368495-Chloro-N-hydroxynicotinimidoyl chloride

생성물 1

HCID 445455443-(5-Chloropyridin-3-yl)-5-(3,4-difluorophenyl)isoxazole

실험 절차

The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 4-ethynyl-1,2-difluorobenzene (Apollo, 41 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.63-7.81 (m, 2H), 7.82 (s, 1H), 8.02 (ddd, J=11.4, 7.6, 2.0 Hz, 1H), 8.41 (t, J=2.0 Hz, 1H), 8.81 (d, J=2.4 Hz, 1H), 9.06 (d, J=2.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 291 (M+H)+, 293 (M+H)+.

출처 및 근거

ORD 기록: ord-7b3261f6343e4177843d083ecddaf8ca
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08383658B2

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