Ammonia → 3-Chloro-5-(3-(pyrazin-2-yl)isoxazol-5-yl)benzonitrile

HRID 390517노트

반응식

HRID 390517 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[N:8][CH:7]=[CH:6][N:5]=1.[Cl:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([C:20]#[CH:21])[CH:19]=1)[C:15]#[N:16].N>>[Cl:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([C:20]2[O:1][N:2]=[C:3]([C:4]3[CH:9]=[N:8][CH:7]=[CH:6][N:5]=3)[CH:21]=2)[CH:19]=1)[C:15]#[N:16]

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 866368483-Chloro-5-ethynylbenzonitrileHCID 136395910N-Hydroxypyrazine-2-carbimidoyl chloride

생성물 1

HCID 445456143-Chloro-5-(3-(pyrazin-2-yl)isoxazol-5-yl)benzonitrile

실험 절차

The titled compound was prepared according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and the product of Example 66A (82 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ7.66 (s, 1H), 7.97 (t, J=1.6 Hz, 1H), 8.30 (d, J=1.6 Hz, 2H), 8.71 (d, J=2.4 Hz, 1H), 8.77 (dd, J=2.8, 1.6 Hz, 1H), 9.31 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 283 (M+H)+, 285 (M+H)+.

출처 및 근거

ORD 기록
ord-21f20e95a1994ba6a6eb6b18bcab9504
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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