Water → (3-Iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid tert-butyl ester

HRID 390560노트

반응식

HRID 390560 반응식
[I:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1.C([O-])([O-])=O.[K+].[K+].Cl[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].O>CN(C=O)C>[C:22]([O:21][C:19](=[O:20])[CH2:18][N:4]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[C:2]([I:1])=[N:3]1)([CH3:25])([CH3:24])[CH3:23]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 66052tert-Butyl chloroacetateHCID 178506575HCID 178506575, 화합물

생성물 1

HCID 57978086(3-Iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid tert-butyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
85 °C

실험 절차

A mixture of 3-iodo-7-azaindazole (25.50 g) and K2CO3 (41.4 g) in DMF (200 mL) was heated to 85° C. and t-butyl chloroacetate (14.3 mL) was slowly added. The mixture was stirred at this temperature for 1 hour (h), cooled to room temperature followed by the addition of water (300 mL). Filtration of the reaction mixture provided (3-iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid tert-butyl ester.

후처리

  1. temperaturecooled to room temperature
  2. filtrationFiltration of the reaction mixture

출처 및 근거

ORD 기록
ord-d2b31d0b2c7c4fb280406fd107ad1bfa
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383630B2

반응 노트

불러오는 중…