(6-Iodopyridin-3-yl)methanol → 6-Iodopyridine-3-carbaldehyde

HRID 390596노트

반응식

HRID 390596 반응식
[I:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+2]>[I:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 23039516(6-Iodopyridin-3-yl)methanol

생성물 1

HCID 534852236-Iodopyridine-3-carbaldehyde수율 74%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6344Dichloromethane용매

실험 절차

86 g (987 mol) of manganese (II) oxide are added to a solution of 23.2 g (98.7 mmol) of (6-iodopyrid-3-yl)methanol in 800 mL of dichloromethane. The reaction mixture is stirred at room temperature for 22 hours. The reaction mixture is filtered through Celite and rinsed with dichloromethane. The filtrate is evaporated under vacuum to give 17 g (74%) of 6-iodopyridine-3-carbaldehyde in the form of a yellow solid.

후처리

  1. filtrationThe reaction mixture is filtered through Celite
  2. washrinsed with dichloromethane
  3. customThe filtrate is evaporated under vacuum

출처 및 근거

ORD 기록
ord-59f54983381a4a138629797dbf0435ea
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383652B2

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