Triethylamine → tert-Butyl 3-bromobenzylcarbamate

HRID 390622노트

반응식

HRID 390622 반응식
Cl.[Br:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH2:7].[C:11](OC([O-])=O)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12].C(N(CC)CC)C>ClCCl>[Br:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH:7][C:11](=[O:12])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 27249803-Bromobenzylamine hydrochlorideHCID 22064466Tert-butyldicarbonate

생성물 1

HCID 11033439tert-Butyl 3-bromobenzylcarbamate수율 102.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 25 g (110 mmol) of 3-bromobenzylamine hydrochloride and 24.5 g (110 mmol) of tert-butyl dicarbonate in 250 mL of dichloromethane in the presence of 15.6 mL (110 mmol) of triethylamine is stirred at room temperature for 16 hours. The reaction medium is washed with water, the phases are separated by settling and the organic phase is dried over sodium sulfate. The solvent is evaporated off and 32.4 g (100%) of tert-butyl (3-bromobenzyl)carbamate are obtained in the form of crystals.

후처리

  1. washThe reaction medium is washed with water
  2. customthe phases are separated
  3. dry with materialthe organic phase is dried over sodium sulfate
  4. customThe solvent is evaporated off

출처 및 근거

ORD 기록
ord-e4f9b643759e42af80358c77fd71f19e
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383652B2

반응 노트

불러오는 중…