Methanol → methyl (Z)-3-(3-butoxy-4-iodophenyl)-2-ethoxyacrylate

HRID 390631노트

반응식

HRID 390631 반응식
[CH2:1]([O:5][C:6]1[CH:7]=[C:8](/[CH:13]=[C:14](\[O:18][CH2:19][CH3:20])/[C:15]([OH:17])=[O:16])[CH:9]=[CH:10][C:11]=1[I:12])[CH2:2][CH2:3][CH3:4].S(=O)(=O)(O)O.O.[CH3:27]O>>[CH2:1]([O:5][C:6]1[CH:7]=[C:8](/[CH:13]=[C:14](\[O:18][CH2:19][CH3:20])/[C:15]([O:17][CH3:27])=[O:16])[CH:9]=[CH:10][C:11]=1[I:12])[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 4

HCID 887MethanolHCID 962WaterHCID 1118Sulfuric AcidHCID 68961569(Z)-3-(3-butoxy-4-iodophenyl)-2-ethoxyacrylic acid

생성물 1

HCID 86626090methyl (Z)-3-(3-butoxy-4-iodophenyl)-2-ethoxyacrylate수율 61%

실험 절차

In an Emrys Optimizer microwave reactor, 0.8 g (2 mmol) of (Z)-3-(3-butoxy-4-iodophenyl)-2-ethoxyacrylic acid is dissolved in 10 mL of methanol and 1 mL of concentrated sulfuric acid and heated at 70° C. by microwave for 2 hours. After addition of water, the reaction medium is extracted with ethyl acetate. The organic phase is washed with water, dried over magnesium sulfate, filtered and evaporated. 0.5 g (61%) of methyl (Z)-3-(3-butoxy-4-iodophenyl)-2-ethoxyacrylate is obtained.

후처리

  1. extractionthe reaction medium is extracted with ethyl acetate
  2. washThe organic phase is washed with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-b4d3a86657794a0c8da4344e60d494dc
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383652B2

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