1,1'-Carbonyldiimidazole → (NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]imidazole-1-carboxamide

HRID 390698

반응식

HRID 390698 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][S:10]/[C:9]/2=[N:13]\[H])=[CH:4][CH:3]=1.[C:15](N1C=CN=C1)([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)=[O:16]>O1CCCC1.ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][S:10]/[C:9]/2=[N:13]\[C:15]([N:17]2[CH:21]=[CH:20][N:19]=[CH:18]2)=[O:16])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 178506456HCID 178506456, 화합물

생성물 1

HCID 87449094(NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]imidazole-1-carboxamide

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

(2Z)-3-(4-Chlorophenyl)-1,3-thiazolidin-2-imine (233 mg, 1.095 mmol, Example 24A) and carbonyldiimidazole (195 mg, 1.205 mmol) in dry tetrahydrofuran were heated at 65° C. After 14 hours the reaction mixture cooled down, diluted with 75 mL of dichloromethane, and washed successively with sodium bicarbonate (50 mL) water and brine (50 mL), dried over magnesium sulfate and concentrated under reduced pressure to give the title compound.

후처리

  1. temperatureAfter 14 hours the reaction mixture cooled down
  2. washwashed successively with sodium bicarbonate (50 mL) water and brine (50 mL)
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-261ba4af212b4acca6e31cb6a1bd37a4
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383657B2

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