6-Bromo-1,1,2,2-tetrafluoro-1,2-dihydronaphthalene → 5,6-Difluoro-2-bromonaphthalene
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](F)([F:12])[C:7](F)([F:14])[CH:6]=[CH:5]2>O1CCCC1.[OH-].[NH4+].ClCCl.[Zn]>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([F:12])=[C:7]([F:14])[CH:6]=[CH:5]2참가 물질
6
실험 절차
Zinc (341 mg, 5.22 mmol) was added to a stirred mixture of 6-bromo-1,1,2,2-tetrafluoro-1,2-dihydronaphthalene (730 mg, 2.60 mmol) in tetrahydrofuran and concentrated ammonium hydroxide (4 mL) at 0° C. The mixture was allowed to warm slowly to room temperature. After 6 hours the reaction was diluted with 35 mL of dichloromethane and extracted. The organic layer was washed with water (2×30 mL) dried and concentrated. The residue was purified by chromatography on silica gel eluting with pentane:hexane (1:1) to provide the title compound.
후처리
- extractionextracted
- washThe organic layer was washed with water (2×30 mL)
- customdried
- concentrationconcentrated
- customThe residue was purified by chromatography on silica gel eluting with pentane:hexane (1:1)
출처 및 근거
- ORD 기록
- ord-362adbe121754d8dbd303511c0643a06
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08383657B2
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