Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → N-(3,5-bis(trifluoromethyl)benzylidene)(2-chloro-5-(trifluoromethyl)phenyl)methanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | P-Toluenesulfonamide | HCID 6269 | — |
| 반응물 | 3,5-Bis(trifluoromethyl)benzaldehyde | HCID 136247 | — |
| 반응물 | 2-Chloro-5-(trifluoromethyl)benzylamine | HCID 2736682 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(3,5-bis(trifluoromethyl)benzylidene)(2-chloro-5-(trifluoromethyl)phenyl)methanamine | HCID 86614963 | — |
반응 단계
To a 100 mL round bottom flask, equipped with a Dean Start Trap was charged 50 mL of toluene, 5.0 gm of 2-chloro-5-trifluoromethyl benzyl amine and 5.8 gm of 3,5-bis(trifluoromethyl)benzaldehyde and 50 mg of para-toluenesulfonamide. The reaction was heated until water no longer distilled off about 3 hours, then cooled to ambient temperature and the solvent removed in vacuum. The crude product was used directly in the next step without further purification. 10.0 gm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383660B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-52125c224296419883ebfc494951e33d |
| 출처 메모 | uspto-grants-2013_02 |