Acetyl chloride → Chloromethyl 2,4-dichlorophenyl ether

HRID 390788

반응식

HRID 390788 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:10]S(C)=O.C([Cl:17])(=O)C>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:10][Cl:17]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 685778492,4-Dichloro-1-methanesulfinylmethoxy-benzene

생성물 1

HCID 12353529Chloromethyl 2,4-dichlorophenyl ether수율 98.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To an ice-water cooled solution of 2,4-dichloro-1-methanesulfinylmethoxy-benzene (8 g, 33.46 mmol) in DCM (100 mL) was added dropwise a solution of acetylchloride (2.6 mL, 36.80 mmol) in DCM (10 mL). The reaction mixture was allowed to reach room temperature during 2 hrs at which time the volatiles were evaporated in vacuo affording ˜7 g of crude 2,4-dichloro-1-chloromethoxy-benzene which was used without further purification.

후처리

  1. customthe volatiles were evaporated in vacuo

출처 및 근거

ORD 기록
ord-8a4b4157fc4e4b759f68fbb32b016ff6
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383683B2

연결된 노트

불러오는 중…