3-Pyridinylboronic acid → 4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)-2-(pyridin-3-yl)furo[3,2-d]pyrimidine

HRID 390930

반응식

HRID 390930 반응식
Cl[C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[O:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([S:18]([CH3:21])(=[O:20])=[O:19])[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[N:28]1[CH:33]=[CH:32][CH:31]=[C:30](B(O)O)[CH:29]=1>>[O:25]1[CH2:26][CH2:27][N:22]([C:4]2[C:5]3[O:10][C:9]([CH2:11][N:12]4[CH2:17][CH2:16][N:15]([S:18]([CH3:21])(=[O:20])=[O:19])[CH2:14][CH2:13]4)=[CH:8][C:6]=3[N:7]=[C:2]([C:30]3[CH:29]=[N:28][CH:33]=[CH:32][CH:31]=3)[N:3]=2)[CH2:23][CH2:24]1

참가 물질

3

반응물 2

HCID 27343783-Pyridinylboronic acidHCID 568337442-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidine

생성물 1

HCID 582338914-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)-2-(pyridin-3-yl)furo[3,2-d]pyrimidine

실험 절차

2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidine (Example 153) was reacted with pyridine-3-boronic acid via General Procedure E to give, after purification by reverse HPLC, 14 mg of 224. MS (Q1) 459 (M+).

후처리

  1. customto give
  2. customafter purification by reverse HPLC, 14 mg of 224

출처 및 근거

ORD 기록
ord-400e4b21886645aab4afdd01cb8b061f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383620B2

연결된 노트

불러오는 중…