5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-(4-morpholino-6-(1-(4-N-methylsulfonylpiperazin-1-yl)ethyl)thieno[3,2-d]pyrimidin-2-yl)pyridin-2-amine
반응식
Cl[C:2]1[N:3]=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:5]2[S:10][C:9]([CH:11]([N:13]3[CH2:18][CH2:17][N:16]([S:19]([CH3:22])(=[O:21])=[O:20])[CH2:15][CH2:14]3)[CH3:12])=[CH:8][C:6]=2[N:7]=1.[NH2:29][C:30]1[CH:35]=[CH:34][C:33](B2OC(C)(C)C(C)(C)O2)=[CH:32][N:31]=1>>[O:26]1[CH2:27][CH2:28][N:23]([C:4]2[C:5]3[S:10][C:9]([CH:11]([N:13]4[CH2:18][CH2:17][N:16]([S:19]([CH3:22])(=[O:21])=[O:20])[CH2:15][CH2:14]4)[CH3:12])=[CH:8][C:6]=3[N:7]=[C:2]([C:33]3[CH:34]=[CH:35][C:30]([NH2:29])=[N:31][CH:32]=3)[N:3]=2)[CH2:24][CH2:25]1참가 물질
3
반응물 2
생성물 1
실험 절차
2-Chloro-6-[1-(4-methanesulfonyl-piperazin-1-yl)-ethyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine was reacted with 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine in General Procedure A. Purification on silica yielded 299. NMR: (CDCl3): 1.43 (3 H, d, J 7.2, Me), 2.56-2.68 (4 H, m, CH2), 2.73 (3 H, s, Me), 3.18-3.29 (4 H, m, CH2), 3.80-3.83 (4 H, m, CH2), 3.94-3.99 (5 H, m), 4.58 (2 H, br s, NH2), 6.48 (1 H, d, J 8.1, Ar), 7.19 (1 H, s, Ar), 8.38 (1 H, dd, J 8.1 and 2.0, Ar) and 9.07 (1 H, d, J 2.0, Ar). MS: (ESI+): MH+=504.26