Citric Acid → Promethazine

HRID 39112

반응식

HRID 39112 반응식
[CH3:1][CH:2]([N:18]([CH3:20])[CH3:19])[CH2:3][N:4]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]1=2.Cl.C=CN1C(=O)CCC1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(O)(=O)/C=C/C=C/C.C(O)[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>O>[CH3:1][CH:2]([N:18]([CH3:19])[CH3:20])[CH2:3][N:4]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=2[S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]1=2

참가 물질

7

반응물 5

HCID 311Citric AcidHCID 5988SucroseHCID 6014Promethazine HydrochlorideHCID 6917N-vinyl-2-pyrrolidoneHCID 643460Sorbic Acid

생성물 1

HCID 4927Promethazine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

22.6 g of promethazine HCl, 25.0 g of polyvinylpyrrolidone K 90 prepared as in Example 8, 5.0 g of citric acid, 2.0 g of sorbic acid and 60.0 g of sucrose were dissolved in 975.0 g of demineralized water at 50° C., and the solution was cooled to room temperature and dispensed into 50 ml amber glass bottles.

출처 및 근거

ORD 기록
ord-ee649061a5d1459fbcf89e3caa807012
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524827B2

연결된 노트

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