6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-2-methylsulfanyl-4-morpholin-4-yl-thieno[2,3-d]pyrimidine → 4-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-2-(5-phenylpyridin-3-yl)thieno[2,3-d]pyrimidin-4-yl)morpholine

HRID 391120노트

반응식

HRID 391120 반응식
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[S:28][C:15]3[N:16]=[C:17](SC)[N:18]=[C:19]([N:20]4[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)[C:14]=3[CH:13]=2)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[C:29]1([C:35]2[CH:36]=[N:37][CH:38]=[C:39]([Sn](CCCC)(CCCC)CCCC)[CH:40]=2)[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>COCCOC.C(OCC)(=O)C.CSC.[Cu]Br.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][S:2]([N:5]1[CH2:6][CH2:7][N:8]([CH2:11][C:12]2[S:28][C:15]3[N:16]=[C:17]([C:39]4[CH:38]=[N:37][CH:36]=[C:35]([C:29]5[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=5)[CH:40]=4)[N:18]=[C:19]([N:20]4[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)[C:14]=3[CH:13]=2)[CH2:9][CH2:10]1)(=[O:3])=[O:4]

참가 물질

7

반응물 2

HCID 666175866-(4-Methanesulfonyl-piperazin-1-ylmethyl)-2-methylsulfanyl-4-morpholin-4-yl-thieno[2,3-d]pyrimidineHCID 669338703-Phenyl-5-tributylstannanyl-pyridine

생성물 1

HCID 249459924-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-2-(5-phenylpyridin-3-yl)thieno[2,3-d]pyrimidin-4-yl)morpholine

시약·촉매·용매 4

HCID 2724234Bromo(thiobis(methane))copper촉매HCID 178418397HCID 178418397, 화합물촉매HCID 80711,2-Dimethoxyethane용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 6-(4-methanesulfonyl-piperazin-1-ylmethyl)-2-methylsulfanyl-4-morpholin-4-yl-thieno[2,3-d]pyrimidine (135 mg) in 1,2-dimethoxyethane (10 mL) was added 3-phenyl-5-tributylstannanyl-pyridine (270 mg) and copper(I)bromide-dimethyl sulfide (125 mg) and the reaction mixture was stirred at room temperature for 10 minutes. Tetrakis(triphenylphosphine)palladium(0) (18 mg) was then added and the reaction mixture was heated at reflux for 16 h. After cooling to room temperature, the mixture was diluted with ethyl acetate (20 mL) and washed with water (2×20 mL) and brine (2×20 mL). The organic phase was dried (MgSO4), reduced in vacuo and purified by column chromatography to give 403. NMR: (CDCl3): 3.17 (3 H, s, Me), 3.93-3.95 (4 H, m), 4.13-4.16 (4 H, m), 5.28 (2 H, s, NH), 7.83 (1 H, t, J 7.0, Ar), 7.92 (1 H, s, Ar), 8.26 (2 H, td, J 7.7 and 1.5, Ar), 8.53-8.54 (1 H, m, Ar) and 9.30 (2 H, s, Ar). MS: (ESI+): MH+ 497.08

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux for 16 h
  3. temperatureAfter cooling to room temperature
  4. washwashed with water (2×20 mL) and brine (2×20 mL)
  5. dry with materialThe organic phase was dried (MgSO4)
  6. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-38409df1c1584a3093e47e88d1e71aa9
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383620B2

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