Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 391169생성일: 2026년 10월 27일
Hexachloroacetone → 7alpha-Chloro-5,6beta-epoxy-15beta,16beta-methylen-3beta-pivaloyloxy-5beta-androstan-17-one
https://huagongshe.com/reaction/391169
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hexachloroacetone | HCID 8303 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 5,6beta-Epoxy-7beta-hydroxy-15beta,16beta-methylen-3beta-pivaloyloxy-5beta-androstan-17-one | HCID 13075958 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 7alpha-Chloro-5,6beta-epoxy-15beta,16beta-methylen-3beta-pivaloyloxy-5beta-androstan-17-one | HCID 13075960 | — |
반응 단계
A solution of 5,6β-epoxy-7β-hydroxy-15β,16β-methylen-3β-pivaloyloxy-5β-androstan-17-one (1.66 g, 0.004 mol) in dichloromethane (8 mL) is treated with hexachloroacetone (2 mL, 0.013 mol) and cooled to 0-2° C. Triphenylphosphine (1.53 g, 0.0044 mol) in dichloromethane (4 mL) is added dropwise and the mixture is stirred for one hour at 3-4° C., then for an additional hour at 10-15° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08383809B2 |
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| 출처 데이터셋 | uspto-grants-2013_02 |
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| ORD ID | ord-52e6f95db59c42b2bf5b9749b4a2da51 |
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| 출처 메모 | uspto-grants-2013_02 |
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