Thionyl Chloride → 2,3-Dihydro-benzo[b]oxepine-4-carbonylchloride

HRID 391277노트

반응식

HRID 391277 반응식
[O:1]1[CH2:7][CH2:6][C:5]([C:8](O)=[O:9])=[CH:4][C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]1=2.S(Cl)([Cl:17])=O>O1CCCC1>[O:1]1[CH2:7][CH2:6][C:5]([C:8]([Cl:17])=[O:9])=[CH:4][C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]1=2

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 11116823HCID 11116823, 화합물

생성물 1

HCID 866497862,3-Dihydro-benzo[b]oxepine-4-carbonylchloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2,3-Dihydro-benzo[b]oxepine-4-carboxylicacid (2.3 mmol) was dissolved in 15 ml tetrahydrofuran. 0.7 ml of thionylchloride were added dropwise and the solution was stirred for two hours. The reaction was quenched by methanol. Methanol and thionylchloride were removed in vacuo yielding 340 mg of 2,3-Dihydro-benzo[b]oxepine-4-carbonylchloride. This was used for step E without further purification.

후처리

  1. customThe reaction was quenched by methanol
  2. customMethanol and thionylchloride were removed in vacuo

출처 및 근거

ORD 기록
ord-51f21275dd8f428581af85e507df0333
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383838B2

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