Potassium Carbonate → Methyl 2-methoxy-5-(2-methyl-2H-tetrazol-5-yl)benzoate

HRID 391395노트

반응식

HRID 391395 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:17][N:16]=[N:15][N:14]=2)=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[C:18](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[N:15][N:16]([CH3:18])[N:17]=2)=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 178497409HCID 178497409, 화합물

생성물 1

HCID 58993674Methyl 2-methoxy-5-(2-methyl-2H-tetrazol-5-yl)benzoate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Methyl 2-methoxy-5-(1H-tetrazol-5-yl)benzoate (0.78 g, 3.33 mmol) methyl iodide (0.21 mL, 3.33 mmol) and potassium carbonate (0.46 g, 3.33 mmol) were combined in acetone (8 mL) and heated at reflux overnight. After cooling to room temperature, the mixture was filtered and concentrated. Flash chromatography on silica gel afforded 170 mg (21%). LC/MS (HPLC method 3): tR=2.01 min, 249.09 (MH)+

후처리

  1. temperatureheated
  2. temperatureat reflux overnight
  3. filtrationthe mixture was filtered
  4. concentrationconcentrated
  5. customFlash chromatography on silica gel afforded 170 mg (21%)

출처 및 근거

ORD 기록
ord-b5e80164e3ea40a7a1227abdfed18de3
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383821B2

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