Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 1-(1,3-Dioxaindan-5-yl)cyclopropane-1-carboxylic acid | HCID 14349608 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride | HCID 59129154 | — |
반응 단계
To an oven-dried round bottom flask containing 1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid (A-8) (618 mg, 3.0 mmol) and CH2Cl2 (3 mL) was added thionyl chloride (1.07 g, 9.0 mmol) and N,N-dimethylformamide (0.1 mL). The reaction mixture was stirred at ambient temperature under an Ar atmosphere until the gas evolution ceased (2-3 h). The excess thionyl chloride was removed under vacuum and the resulting residue dissolved in CH2Cl2 (3 mL). The mixture was used without further manipulation.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524767B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-149e3eca1b604a8aa9b6b65372c7188b |
| 출처 메모 | uspto-grants-2013_09 |