5-(2-Phenyleth-1-Ynyl)Nicotinic Acid → HCID 24952432, 화합물

HRID 391511

반응식

HRID 391511 반응식
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[N:11][CH:12]=[C:13]([CH:17]=2)[C:14]([OH:16])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][S@@:19]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[NH:21])=[O:20]>>[CH3:18][S@@:19](=[O:20])([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[N:21][C:14](=[O:16])[C:13]1[CH:17]=[C:9]([C:8]#[C:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:10]=[N:11][CH:12]=1

참가 물질

3

반응물 2

HCID 27792365-(2-Phenyleth-1-Ynyl)Nicotinic AcidHCID 25036286[S(R)]-S-Methyl-S-phenylsulfoximine

생성물 1

HCID 24952432HCID 24952432, 화합물수율 25%

실험 절차

In a manner similar to that described in Example 423, 5-(2-phenyleth-1-ynyl)nicotinic acid and (R)-(−)-S-methyl-S-phenylsulfoximine were reacted to give the title compound as a white foam (54 mg, 25%).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-7a315afa3c2647d79eb8c56dfb2b5326
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383825B2

연결된 노트

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