tert-Butyl 3-ethynylphenylcarbamate → (S)-tert-butyl (3-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}phenyl)carbamate

HRID 391550

반응식

HRID 391550 반응식
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH:6]=[CH:7][CH:8]=1)#[CH:2].Br[C:18]1[CH:19]=[N:20][CH:21]=[C:22]([CH:35]=1)[C:23]([N:25]=[S@@:26]([CH3:34])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:24]>>[CH3:34][S@:26](=[N:25][C:23]([C:22]1[CH:35]=[C:18]([C:2]#[C:1][C:3]2[CH:4]=[C:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[CH:6]=[CH:7][CH:8]=2)[CH:19]=[N:20][CH:21]=1)=[O:24])(=[O:33])[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

참가 물질

3

반응물 2

HCID 11275982tert-Butyl 3-ethynylphenylcarbamateHCID 86629466(S)-5-bromo-N-[methyl(oxido)phenyl--sulfanylidene]nicotinamide

생성물 1

HCID 24953492(S)-tert-butyl (3-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}phenyl)carbamate수율 23%

실험 절차

In a manner similar to that described in Example 449, tert-butyl 3-ethynylphenylcarbamate (0.098 g, 0.443 mmol) and (S)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide (0.100 g, 0.295 mmol) reacted to give the title compounds as a white solid (32 mg, 23%).

후처리

  1. customreacted

출처 및 근거

ORD 기록
ord-ee5b333ba71f4960bab3fcdacc19b949
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383825B2

연결된 노트

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