(Diethylamino)trimethylsilane → (S)-trimethyl{[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}silane

HRID 391566

반응식

HRID 391566 반응식
[CH3:1][S@:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[NH:4])=[O:3].[CH3:11][Si:12](N(CC)CC)([CH3:14])[CH3:13]>C(#N)C>[CH3:11][Si:12]([CH3:14])([CH3:13])[N:4]=[S@@:2]([CH3:1])(=[O:3])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 70454(Diethylamino)trimethylsilane2회HCID 25036288(S)-(+)-S-Methyl-S-phenylsulfoximine

생성물 1

HCID 25041124(S)-trimethyl{[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}silane

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
65 °C

실험 절차

To a stirred pre-warmed solution of (S)-(+)-S-methyl-S-phenylsulphoximine (3 g, 18.7 mmol) in acetonitrile (2 mL) at 65° C. was added (trimethylsilyl)diethylamine (4.12 g, 21.1 mmol) dropwise via a syringe. The reaction was maintained at 65° C. and stirred for 3 hours. Additional amount of (trimethylsilyl)diethylamine (2 mL, 10.2 mmol) was added and the reaction mixture was stirred at 65° C. overnight. The reaction was then concentrated under reduced pressure and dried under vacuum to give the title compound. This material was used directly in next step of the synthesis without further purification.

후처리

  1. stirringthe reaction mixture was stirred at 65° C. overnight
  2. concentrationThe reaction was then concentrated under reduced pressure
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-8440d5b05f374f379ffa4ec1ef4a9cee
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383825B2

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