Methyl 3-{N-[(5-bromopyridin-3-yl)carbonyl]-S-methylsulfonimidoyl}benzoate → methyl 3-[N-({5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]benzoate

HRID 391599

반응식

HRID 391599 반응식
Br[C:2]1[CH:3]=[C:4]([C:8]([N:10]=[S:11]([C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=2)[C:17]([O:19][CH3:20])=[O:18])([CH3:13])=[O:12])=[O:9])[CH:5]=[N:6][CH:7]=1.[C:24]([C:26]1[CH:27]=[C:28]([NH:32][C:33]([C:35]2[N:39]([CH3:40])[N:38]=[C:37]([CH3:41])[CH:36]=2)=[O:34])[CH:29]=[CH:30][CH:31]=1)#[CH:25]>>[CH3:40][N:39]1[C:35]([C:33]([NH:32][C:28]2[CH:27]=[C:26]([C:24]#[C:25][C:2]3[CH:3]=[C:4]([C:8]([N:10]=[S:11]([C:14]4[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=4)[C:17]([O:19][CH3:20])=[O:18])([CH3:13])=[O:12])=[O:9])[CH:5]=[N:6][CH:7]=3)[CH:31]=[CH:30][CH:29]=2)=[O:34])=[CH:36][C:37]([CH3:41])=[N:38]1

참가 물질

3

반응물 2

HCID 57657891Methyl 3-{N-[(5-bromopyridin-3-yl)carbonyl]-S-methylsulfonimidoyl}benzoateHCID 57657904N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

생성물 1

HCID 57657956methyl 3-[N-({5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]benzoate

실험 절차

In a manner similar to that described in Example 460, methyl 3-{N-[(5-bromopyridin-3-yl)carbonyl]-S-methylsulfonimidoyl}benzoate and N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide were reacted to give the title compound.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-d4527f5e48d34dd5a311a88f427aff4e
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383825B2

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