Dichloromethane → 9-(Cyclohexylmethyl)-2-(3-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide

HRID 391688노트

반응식

HRID 391688 반응식
[NH2:1]/[C:2](/[C:17]#[N:18])=[C:3](\[NH:6][C:7]([NH:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:8])/[C:4]#[N:5].N/[C:20](=[C:23](\N)/C#N)/[C:21]#N.N(CC1CCCCC1)=C=[O:29].ClCCl.[O:40]1[CH2:44][CH2:43][CH2:42][CH2:41]1>>[CH:11]1([CH2:10][N:9]2[C:7](=[O:8])[NH:6][C:3]3[C:4]2=[N:5][C:41]([C:42]2[CH:23]=[CH:20][CH:21]=[C:44]([OH:40])[CH:43]=2)=[N:1][C:2]=3[C:17]([NH2:18])=[O:29])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

6

반응물 5

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 2723951DiaminomaleonitrileHCID 3414518(Isocyanatomethyl)cyclohexaneHCID 57474758(Z)-1-(2-Amino-1,2-dicyanovinyl)-3-(cyclohexylmethyl)urea

생성물 1

HCID 574747579-(Cyclohexylmethyl)-2-(3-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide수율 47%

실험 절차

(Z)-1-(2-Amino-1,2-dicyanovinyl)-3-(cyclohexylmethyl)urea. 2,3-Diaminomaleonitrile (0.119 g, 1.10 mmol) and (isocyanatomethyl)cyclohexane (0.140 g, 1.00 mmol) in tetrahydrofuran (2 mL) were reacted according to General Procedure A. Dichloromethane and hexanes were added to the solution and the resultant precipitate was filtered and dried to afford the title compound (0.200 g, 47%). MS (ESI) m/z 248.2 [M+1]+.

후처리

  1. filtrationthe resultant precipitate was filtered
  2. customdried

출처 및 근거

ORD 기록
ord-762ae629ad1342e6b1665755ac5b6dba
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383634B2

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