Acetic Acid → 2-Amino-6-(fluoromethyl)pyrimidin-4(1h)-one

HRID 3917

반응식

HRID 3917 반응식
[NH2:1][C:2]1[N:7]=[C:6](F)[CH:5]=[C:4]([CH2:9][F:10])[N:3]=1.C(O)(=[O:13])C>>[NH2:1][C:2]1[NH:7][C:6](=[O:13])[CH:5]=[C:4]([CH2:9][F:10])[N:3]=1

참가 물질

3

반응물 2

HCID 176Acetic AcidHCID 201534984-Fluoro-6-(fluoromethyl)pyrimidin-2-amine

생성물 1

HCID 1355279702-Amino-6-(fluoromethyl)pyrimidin-4(1h)-one

실험 절차

12.1 Parts of 2-amino-4-fluoro-6-fluoromethylpyrimidine was dissolved in 200 parts of 20% aqueous acetic acid at reflux, with stirring. The mixture was heated under reflux for 1 hour then cooled. The precipitated solid was filtered, washed with 50% aqueous acetic acid and then with acetone. The solid was dried in vacuo at 140° C. to give 2-amino-6-fluoromethylpyrimidine-4-one, m.p. 237°-238° C. (decomposition).

후처리

  1. temperatureat reflux
  2. temperatureThe mixture was heated
  3. temperatureunder reflux for 1 hour
  4. temperaturethen cooled
  5. filtrationThe precipitated solid was filtered
  6. washwashed with 50% aqueous acetic acid
  7. customThe solid was dried in vacuo at 140° C.

출처 및 근거

ORD 기록
ord-f197a439b25842d9882c6684168e87b0
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723006

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