Peracetic Acid → 6,7-Dihydro-5H-cyclopenta[b]pyridine 1-oxide

HRID 391784

반응식

HRID 391784 반응식
[N:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.C(OO)(=[O:12])C>C(Cl)Cl>[N+:1]1([O-:12])[C:9]2[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 6585Peracetic AcidHCID 68292Pyrindan

생성물 1

HCID 131533156,7-Dihydro-5H-cyclopenta[b]pyridine 1-oxide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

N-oxide formation also was performed under the following conditions. To a 6,7-dihydro-5H-[1]pyrindine solution in DCM at 0° C. was added peracetic acid (3 mL, 32% in AcOH), and the reaction was slowly allowed to come to rt and stirred for 12 h. The reaction mixture was diluted with DCM (5 mL) and washed with water, aq NaHCO3, brine, then dried over Na2SO4, filtered and concentrated to afford desired 6,7-dihydro-5H-[1]pyrindine 1-oxide (0.6 g). LCMS (m/z): 136.

후처리

  1. customto come to rt
  2. washwashed with water, aq NaHCO3, brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5f949f76b1e847f79d06363480c08628
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383644B2

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