4-Iodobenzonitrile → (S)-8-[(S)-4-(4-cyano-phenyl)-1 methoxycarbonyl-but-3-ynylcarbamoyl]-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-2,3,8,9-tetrahydro-6H-[1,4]dioxino[2,3-g]isoquinoline-7-carboxylic acid tert-butyl ester

반응식

C(OC([N:8]1C(C(O)=O)C[C:15]2[CH:14]=[C:13]3OC[C@H](C4C=CC(OCC5C=CC(Cl)=C(Cl)C=5)=CC=4)O[C:12]3=[CH:11][C:10]=2[CH2:9]1)=O)(C)(C)C.[C:41]([O:45][C:46]([N:48]1[CH:57]([C:58](=[O:68])[NH:59][C@H:60]([C:64]([O:66][CH3:67])=[O:65])[CH2:61][C:62]#[CH:63])[CH2:56][C:55]2[CH:54]=[C:53]3[O:69][CH2:70][C@H:71]([C:73]4[CH:78]=[CH:77][C:76]([O:79][CH2:80][C:81]5[CH:86]=[CH:85][C:84]([Cl:87])=[C:83]([Cl:88])[CH:82]=5)=[CH:75][CH:74]=4)[O:72][C:52]3=[CH:51][C:50]=2[CH2:49]1)=[O:47])([CH3:44])([CH3:43])[CH3:42].IC1C=CC(C#N)=CC=1>>[C:41]([O:45][C:46]([N:48]1[CH:57]([C:58](=[O:68])[NH:59][C@H:60]([C:64]([O:66][CH3:67])=[O:65])[CH2:61][C:62]#[C:63][C:13]2[CH:12]=[CH:11][C:10]([C:9]#[N:8])=[CH:15][CH:14]=2)[CH2:56][C:55]2[CH:54]=[C:53]3[O:69][CH2:70][C@H:71]([C:73]4[CH:74]=[CH:75][C:76]([O:79][CH2:80][C:81]5[CH:86]=[CH:85][C:84]([Cl:87])=[C:83]([Cl:88])[CH:82]=5)=[CH:77][CH:78]=4)[O:72][C:52]3=[CH:51][C:50]=2[CH2:49]1)=[O:47])([CH3:44])([CH3:42])[CH3:43]