Veratric Acid → (S)-2-{[(3S,8S)-3-[4-(3,4-Dichloro-benzyloxy)-phenyl]-7-(3,4-dimethoxy-benzoyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl]-amino}-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid

HRID 391963노트

반응식

HRID 391963 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([OH:8])=O.CCN=C=NCCCN(C)C.C[O:26][C:27](=[O:78])[C@@H:28]([NH:45][C:46]([C@@H:48]1[CH2:57][C:56]2[CH:55]=[C:54]3[O:58][CH2:59][C@H:60]([C:62]4[CH:67]=[CH:66][C:65]([O:68][CH2:69][C:70]5[CH:75]=[CH:74][C:73]([Cl:76])=[C:72]([Cl:77])[CH:71]=5)=[CH:64][CH:63]=4)[O:61][C:53]3=[CH:52][C:51]=2[CH2:50][NH:49]1)=[O:47])[CH2:29][C:30]1[CH:35]=[CH:34][C:33]([O:36][C:37]2[CH:42]=[CH:41][N:40]=[C:39]([CH3:43])[C:38]=2[CH3:44])=[CH:32][CH:31]=1>C(Cl)Cl>[Cl:77][C:72]1[CH:71]=[C:70]([CH:75]=[CH:74][C:73]=1[Cl:76])[CH2:69][O:68][C:65]1[CH:66]=[CH:67][C:62]([C@H:60]2[CH2:59][O:58][C:54]3=[CH:55][C:56]4[CH2:57][C@@H:48]([C:46]([NH:45][C@@H:28]([CH2:29][C:30]5[CH:35]=[CH:34][C:33]([O:36][C:37]6[CH:42]=[CH:41][N:40]=[C:39]([CH3:43])[C:38]=6[CH3:44])=[CH:32][CH:31]=5)[C:27]([OH:78])=[O:26])=[O:47])[N:49]([C:6](=[O:8])[C:5]5[CH:9]=[CH:10][C:11]([O:12][CH3:13])=[C:3]([O:2][CH3:1])[CH:4]=5)[CH2:50][C:51]=4[CH:52]=[C:53]3[O:61]2)=[CH:63][CH:64]=1

참가 물질

5

반응물 3

HCID 7121Veratric AcidHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 58327121(S)-2-({(3S,8S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl}-amino)-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester

생성물 1

HCID 58327502(S)-2-{[(3S,8S)-3-[4-(3,4-Dichloro-benzyloxy)-phenyl]-7-(3,4-dimethoxy-benzoyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl]-amino}-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3,4-Dimethoxybenzoic acid (1 eq.) was stirred in dry DCM with 0.5 eq EDCI at RT for 1 h. (S)-2-({(3S,8S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl}-amino)-3-[4-(2,3-dimethyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester in dry DCM (10 eq benzoic acid relative to amine) was added and the resulting mixture stirred 16 h, then directly purified by flash chromatography. The resulting compound was hydrolyzed according to General Procedure B to give the title compound (5 mg). LCMS (m/z) 919.

후처리

  1. additionwas added
  2. customdirectly purified by flash chromatography

출처 및 근거

ORD 기록
ord-c3c74fd8c2454052bc34998114730cdb
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383644B2

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