Thionyl Chloride → HCID 10879289, 화합물

HRID 392060노트

반응식

HRID 392060 반응식
[CH:1]1[C:14]2[N:13]([CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)S[C:5]=2[CH:4]=[CH:3][CH:2]=1.N=CCCC(CC1C=CC=CC=1)(CC1C=CC=CC=1)O.S(Cl)(Cl)=O>C1C=CC=CC=1>[C:12]1([N:13]([C:14]2[CH:1]=[CH:2][CH:3]=[CH:4][CH:5]=2)[CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 1114022010H-Phenothiazine-10-butanolHCID 22662683HCID 22662683, 화합물

생성물 1

HCID 10879289HCID 10879289, 화합물

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To prepare compounds 6a, 6b and 6e, to a solution of 5a (2.03 g, 7.5 mmol), 5b or 5e in 100 ml of dry benzene was added thionyl chloride (2 ml, 10 mmol) and stirred overnight at room temperature. After solvent evaporation, the residue was chromatographed on silica gel column. Elution with 10% ethyl acetate/hexanes afforded the following compounds:

후처리

  1. customAfter solvent evaporation
  2. customthe residue was chromatographed on silica gel column
  3. washElution with 10% ethyl acetate/hexanes
  4. customafforded the following compounds

출처 및 근거

ORD 기록
ord-735e3cac9b934c0f8773f833d4f12b59
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06800618B2

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