2-Aminothiophenol → 2-(Chloromethyl)benzothiazole

HRID 3921

반응식

HRID 3921 반응식
[Cl:1][CH2:2][C:3](OCC)(OCC)OCC.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[SH:20]>C(Cl)Cl>[Cl:1][CH2:2][C:3]1[S:20][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=1

참가 물질

4

반응물 2

HCID 87132-AminothiophenolHCID 3059222-Chloro-1,1,1-triethoxyethane

생성물 1

HCID 3049782-(Chloromethyl)benzothiazole수율 91.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.

후처리

  1. washthe resulting solution was washed with 3N HCl (10 ml)
  2. customThe organic portion was evaporated
  3. customthe residue chromatographed over silica gel

출처 및 근거

ORD 기록
ord-7628ca281c8a4d939d7e63b118d19a45
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723010

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