Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium ethoxide → 4-Azaindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide | HCID 12146853 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Azaindole | HCID 9226 | — |
반응 단계
A mixture of 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide (1.0 eq) and sodium ethoxide (5 eq.) in ethanol is heated at reflux temperature for 10 h, cooled and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to give the title 4-azaindole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06800640B2 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-2930650ca1d249b885405ad26de4d25a |
| 출처 메모 | uspto-grants-2004_10 |