참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Nitropyridine | HCID 137630 | — |
| 반응물 | HCID 178418507 | HCID 178418507 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 6-Azaindole | HCID 9219 | — |
반응 단계
A solution of 3-nitropyridine in THF at −78° C. is treated with vinyl magnesium bromide (3 eq), stirred at −20° C. for 8 h and quenched with 20% ammonium chloride. The phases are separated and the aqueous phase is extracted with EtOAc. The organic phase and the combined extracts are mixed together, dried over MgSO4 and concentrated in vacuo. The resultant residue is chromatographed over silica gel to afford the title 6-azaindole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06800640B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_10 |
|---|
| ORD ID | ord-74628ef804be4d30a069d0b6e8947871 |
|---|
| 출처 메모 | uspto-grants-2004_10 |
|---|
