Water → Ethyl 3-(octahydroquinolin-1-yl)-3-oxopropionate

HRID 39215

반응식

HRID 39215 반응식
CCN(CC)CC.Cl[C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].[NH:17]1[CH:26]2[CH:21]([CH2:22][CH2:23][CH2:24][CH2:25]2)[CH2:20][CH2:19][CH2:18]1.O>CCOC(C)=O>[N:17]1([C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:26]2[CH:21]([CH2:22][CH2:23][CH2:24][CH2:25]2)[CH2:20][CH2:19][CH2:18]1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 92911DecahydroquinolineHCID 118931Ethyl 3-chloro-3-oxopropionate

생성물 1

HCID 66794569Ethyl 3-(octahydroquinolin-1-yl)-3-oxopropionate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3.38 mL of Et3N and 1.44 mL (11 mmol) of ethyl 3-chloro-3-oxopropionate are added to a solution of 1.5 mL (10 mmol) of decahydroquinoline in 100 mL of AcOEt. The resulting solution is kept under stirring at reflux for 10 h. Then water is added and the organic phase is separated, the aqueous phase is extracted once again with AcOEt. The organic phases are pooled and they are first washed with 5% solution of NaHCO3 and subsequently with brine, they are dried over anhydrous

후처리

  1. temperatureat reflux for 10 h
  2. customthe organic phase is separated
  3. extractionthe aqueous phase is extracted once again with AcOEt
  4. washthey are first washed with 5% solution of NaHCO3 and subsequently with brine, they
  5. customare dried over anhydrous

출처 및 근거

ORD 기록
ord-7b31eb19252f4fb084552a23f4201ee8
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524894B2

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