Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Octahydroquinoline-1-carboxylic acid 3-chloropropylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Decahydroquinoline | HCID 92911 | — |
| 반응물 | Propane, 1-chloro-3-isocyanato- | HCID 166752 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Octahydroquinoline-1-carboxylic acid 3-chloropropylamide | HCID 66795223 | 84.6% |
반응 단계
2.5 g (21 mmol) of 3-chloropropylisocyanate are dissolved in 150 mL of anhydrous THF and 6.4 mL (46 mmol) of Et3N. Once dissolved 3.4 mL (23 mmol) of decahydroquinoline are slowly added and it is refluxed for 18 h. AcOEt is then added and the resulting solution is sequentially washed with water, 1N HCl and brine. The organic phase is dried over anhydrous Na2SO4, it is filtered and the solvent is evaporated under reduced pressure yielding 4.6 g of intermediate IIIf.1. Method B: tr: 3.58 min; m/z: 259
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524894B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-815daed69aa74be79cf96e08165c9842 |
| 출처 메모 | uspto-grants-2013_09 |