Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiazolidine → 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiazolidine | HCID 10444 | — |
| 반응물 | 2-Cyano-3-difluoromethoxyphenylsulfonyl chloride | HCID 58100767 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile | HCID 44199441 | — |
반응 단계
54 mg of 2-cyano-3-difluoromethoxy-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 32 I of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by HPLC affords 35 mg of 2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524896B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-4e03c46cba5d4544802825dfbdd6204e |
| 출처 메모 | uspto-grants-2013_09 |