Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiazolidine → 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiazolidine | HCID 10444 | — |
| 반응물 | 2-Cyano-3-fluorobenzene-1-sulfonyl chloride | HCID 20505212 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile | HCID 44218655 | — |
반응 단계
440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524896B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-62d17e228e394a5fafc800d9e62ffeab |
| 출처 메모 | uspto-grants-2013_09 |