Chloroacetyl chloride → 2-Chloromethyl-3-(2-chlorophenyl)-6,7-dimethoxy-3H-quinazolin-4-one

참여 물질

역할	이름	HCID	투입량
반응물	Chloroacetyl chloride	HCID 6577	—
반응물	2-amino-N-(2-chlorophenyl)-4,5-dimethoxybenzamide	HCID 14127143	—
용매	Acetic Acid	HCID 176	—
생성물	2-Chloromethyl-3-(2-chlorophenyl)-6,7-dimethoxy-3H-quinazolin-4-one	HCID 22316558	46%

반응 단계

Prepared according to Procedure B with 1a (2.95 g, 9.63 mmol) and chloroacetyl chloride (2.3 mL, 28.9 mmol) in acetic acid (30 mL). Purified by extraction from aq. K2CO3 and recrystallization from isopropanol to afford 1.61 g of a brown crystalline solid (46%). 1H NMR (CDCl3) δ: 7.59-7.66 (m, 2H); 7.45-7.56 (m, 3H); 7.20 (s, 1H); 4.37 (d, J=12 Hz, 1H), 4.08 (d, J=12 Hz, 1H); 4.04 (s, 3H); 4.00 (s, 3H). MS (ES): m/z 365.0 (M+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06800620B2
출처 데이터셋	uspto-grants-2004_10
ORD ID	ord-718b1bb7495d47d9a1187428e1041253
출처 메모	uspto-grants-2004_10