Sodium periodate → HCID 44218659, 화합물

HRID 39225

반응식

HRID 39225 반응식
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10]([N:13]2[CH2:17][CH2:16][S:15][CH2:14]2)(=[O:12])=[O:11])[C:3]=1[C:4]#[N:5].I([O-])(=O)(=O)=[O:19].[Na+]>CO.O>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10]([N:13]2[CH2:17][CH2:16][S:15](=[O:19])[CH2:14]2)(=[O:12])=[O:11])[C:3]=1[C:4]#[N:5]

참가 물질

5

반응물 2

HCID 23667635Sodium periodateHCID 442186552-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

생성물 1

HCID 44218659HCID 44218659, 화합물수율 70%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

54 mg of 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile in 10 ml of methanol and 1 ml of water are treated with 45 mg of sodium periodate, and the mixture is stirred for 14 hours at room temperature. The reaction mixture is poured into water, and the aqueous layer is extracted three times with ethyl acetate. The combined organic layers are dried over sodium sulfate, filtered and concentrated in vacuo. Purification by reverse phase HPLC affords 40 mg of 2-Fluoro-6-(1-oxo-1 lambda*4*-thiazolidine-3-sulfonyl)-benzonitrile.

후처리

  1. extractionthe aqueous layer is extracted three times with ethyl acetate
  2. dry with materialThe combined organic layers are dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customPurification by reverse phase HPLC

출처 및 근거

ORD 기록
ord-fd5234d09edb41feb82f3dd1a0012650
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524896B2

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