Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → 5-Chloro-2-chloromethyl-3-(2-fluorophenyl)-3H-quinazolin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | 2-amino-6-chloro-N-(2-fluorophenyl)benzamide | HCID 22316580 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 5-Chloro-2-chloromethyl-3-(2-fluorophenyl)-3H-quinazolin-4-one | HCID 22316557 | 40% |
반응 단계
Prepared according to Procedure B with 1k (1.0 g, 3.78 mmol) and chloroacetyl chloride (0.90 mL, 11.3 mmol) in acetic acid (20 mL). Purified by chromatography in CH2Cl2 to afford 484 mg of a pale pink solid (40%). 1H NMR (CDCl3) δ: 7.69 (s, 1H); 7.68 (d, J=3.2 Hz, 1H); 7.56 (d, J=3.0 Hz, 1H); 7.54 (d, J=3.0 Hz, 1H); 7.40-7.47 (m, 1H); 7.35-7.38 (m, 1H); 7.27-7.32 (m, 1H); 4.35 (d, J=12 Hz, 1H); 4.18 (d, J=12 Hz, 1H). MS (ES): m/z 323.0 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06800620B2 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-26dcda7a6baa49979e8d848eb61f150e |
| 출처 메모 | uspto-grants-2004_10 |