2-Amino-3-Hydroxypyridine → 2-(Chloromethyl)(1,3)oxazolo(4,5-b)pyridine

HRID 3923

반응식

HRID 3923 반응식
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:9][CH2:10][C:11](OCC)(OCC)OCC>COCCOCCOC>[Cl:9][CH2:10][C:11]1[O:8][C:7]2[C:2]([N:1]=1)=[N:3][CH:4]=[CH:5][CH:6]=2

참가 물질

4

반응물 2

HCID 281142-Amino-3-HydroxypyridineHCID 3059222-Chloro-1,1,1-triethoxyethane

생성물 1

HCID 27645692-(Chloromethyl)(1,3)oxazolo(4,5-b)pyridine

시약·촉매·용매 1

HCID 8150Diglyme용매

실험 절차

The commercially available 2-amino-3-hydroxypyridine (5.0 g) and diglyme (30 ml) were heated at 125° C. to obtain a solution. To this solution was added 2-chloro-1,1,1-triethoxyethane (9.9 g) and the mixture was held at 125° for 1 hour. The solution was cooled to room temperature and then decanted to remove a black byproduct residue. The filtrate was diluted with water (50 ml) and the resulting yellow precipitate was collected (1.5 g). A small sample was crystallized from isopropanol (m.p. 115°-118° C.).

후처리

  1. customto obtain a solution
  2. customdecanted
  3. customto remove a black byproduct residue
  4. additionThe filtrate was diluted with water (50 ml)
  5. customthe resulting yellow precipitate was collected (1.5 g)
  6. customA small sample was crystallized from isopropanol (m.p. 115°-118° C.)

출처 및 근거

ORD 기록
ord-3b3a232422e4466d95c7b4b7201b4772
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723010

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