3-(4-Nitrophenyl)prop-2-enal → (E,E)-2-(Benzylaminocarbonyl)-3-(4-nitrostyryl)acrylonitrile

HRID 392482노트

반응식

HRID 392482 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([CH:8]=[CH:9][CH:10]=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:14]([CH2:16][C:17]([N-:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])#[N:15]>>[CH2:20]([NH:19][C:17](/[C:16](=[CH:10]/[CH:9]=[CH:8]/[C:7]1[CH:12]=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)/[C:14]#[N:15])=[O:18])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

3

반응물 2

HCID 156143-(4-Nitrophenyl)prop-2-enalHCID 178511179N-(cyanoacetyl)benzylamide

생성물 1

HCID 9858847(E,E)-2-(Benzylaminocarbonyl)-3-(4-nitrostyryl)acrylonitrile수율 82.5%

실험 절차

The compound was prepared as described in Example 3 by adding 4-nitrocinnamaldehyde (0.022 g, 0.12 mmol) to N-(cyanoacetyl)benzylamide (Example 4, 0.022 g, 0.12 mmol). After refluxing for 1 h, the product was purified by silica gel chromatography (CHCl3-MeOH, 5:1) to give a yellow solid (0.033 g, 81%) The product gave the following analytical data:

후처리

  1. customThe compound was prepared
  2. temperatureAfter refluxing for 1 h
  3. customthe product was purified by silica gel chromatography (CHCl3-MeOH, 5:1)

출처 및 근거

ORD 기록
ord-4be7cbb7f1b7495ca26935f24b73548b
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06800659B2

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