2,2-dimethoxyethyl N-benzyloxycarbonylglycine → 2,2-Dimethoxyethyl glycine

HRID 39249

반응식

HRID 39249 반응식
[CH3:1][O:2][CH:3]([O:20][CH3:21])[CH2:4][N:5](C(OCC1C=CC=CC=1)=O)[CH2:6][C:7]([OH:9])=[O:8]>C1COCC1.[Pd]>[CH3:21][O:20][CH:3]([O:2][CH3:1])[CH2:4][NH:5][CH2:6][C:7]([OH:9])=[O:8]

참가 물질

4

반응물 1

HCID 671854852,2-dimethoxyethyl N-benzyloxycarbonylglycine

생성물 1

HCID 193615392,2-Dimethoxyethyl glycine수율 77.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of compound 37 (425 mg, 1.43 mmol) dissolved in 20 mL of anhydrous THF in a Parr apparatus for hydrogenation, was added 160 mg of 10% Pd/C, the system was charged with 60 psi of H2, and the bottle was shaken for 2 h. The catalyst was filtered over Celite, washed with 20 mL of ethyl acetate and the combined filtrate was concentrated in vacuo to give 38 (180 mg, 77%). 1H NMR (400 MHz, CDCl3) δ 3.36 (s, 6H), 3.42 (s, 2H), 4.08 (d, J=5.3 Hz, 2H), 4.54 (t, J=5.3 Hz, 1H).

후처리

  1. additionthe system was charged with 60 psi of H2
  2. filtrationThe catalyst was filtered over Celite
  3. washwashed with 20 mL of ethyl acetate
  4. concentrationthe combined filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-3fb39e9d7c8241268885ef176626c218
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524691B2

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