Phosgene → Benzeneacetyl chloride, 4-(acetyloxy)-

HRID 39257

반응식

HRID 39257 반응식
[C:1]([Cl:4])(Cl)=[O:2].[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15]O)=[CH:11][CH:10]=1)(=[O:7])[CH3:6]>C1(C)C=CC=CC=1>[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:1]([Cl:4])=[O:2])=[CH:11][CH:10]=1)(=[O:7])[CH3:6]

참가 물질

4

반응물 2

HCID 6371PhosgeneHCID 959064-Acetoxybenzyl alcohol

생성물 1

HCID 182488Benzeneacetyl chloride, 4-(acetyloxy)-

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

To a solution of phosgene in toluene (20% w/w, 2.2 mL, 4.2 mmol), cooled in an ice bath, was added dropwise a solution of 60 (321 mg, 1.9 mmol) in 2 mL of toluene. The mixture was stirred in the same bath, which was left to come to room temperature on its own. After 18 h, the mixture was concentrated in vacuo to give 61, which was used in the next step without further purification. 1H NMR (400 MHz, CDCl3) δ 2.30 (s, 3H), 5.28 (s, 2H), 7.13 (d, J=8.6 Hz, 2H), 7.42 (d, J=8.7 Hz, 2H).

후처리

  1. waitwas left
  2. customto come to room temperature on its
  3. concentrationthe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-92490217d32c40b8aa54f432ecaf61a4
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524691B2

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