참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tin tetrachloride | HCID 24287 | — |
| 반응물 | ethyl 2-(1H-1,3-benzodiazol-2-yl)acetate | HCID 308071 | — |
| 반응물 | 2-Amino-5-(4-methyl-1-piperazinyl)benzonitrile | HCID 21928519 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | HCID 178480624 | HCID 178480624 | — |
반응 단계
Ethyl 2-benzimidazol-2-ylacetate (1.1 eq) and 2-amino-5-(4-methylpiperazinyl)benzenecarbonitrile (1.0 eq) were dissolved in 1,2-dichloroethane, and then SnCl4 (11 eq) was added. The mixture was heated at reflux overnight. Upon cooling, the mixture was concentrated in vacuo. NaOH (3 M) was added to the solid, and the mixture heated at 80° C. for 0.5 hours. The solid was filtered and washed sequentially with H2O, CH2Cl2, and acetone. LC/MS indicated that the product was present in the acetone layer and the solid. These fractions were combined and purified by silica gel chromatography (5-10% MeOH in CH2Cl2 with 1% Et3N) to give the desired product. LC/MS m/z 375.4 (MH+), Rf 1.65 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06800760B2 |
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| 출처 데이터셋 | uspto-grants-2004_10 |
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| ORD ID | ord-f2e1585b151d40ecb98e8ce46ec367ea |
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| 출처 메모 | uspto-grants-2004_10 |
|---|
