4-Fluorobenzyl chloride → HCID 3757313, 화합물

반응식

[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Cl)=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][O:1][C:2]2[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=2)[C:5]([O:7][CH3:8])=[O:6])=[CH:15][CH:14]=1

참가 물질

반응물 2

HCID 96024-Fluorobenzyl chloride

HCID 88068Methyl 3-Hydroxybenzoate

생성물 1

HCID 3757313HCID 3757313, 화합물

실험 절차

Reaction of methyl 3-hydroxybenzoate with p-fluorobenzyl chloride as described in the preparation of Intermediate 1A gave the title ester as white prisms: mp 58-59° C. (hexane). 1HNMR 400 MHz (CDCl3) δ (ppm): 3.94 (3H, s, OCH3), 5.1 (2H, s, OCH2), 7.09-7.69 (8H, m, aromatics). Anal. Calcd for C15H13FO3: C, 69.22; H, 5.03. Found: C, 69.08; H, 4.97.

출처 및 근거

ORD 기록: ord-2f52b8cac8d74721942e4e4d04e6f71b
출처 데이터셋: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06803378B2

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