Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate | HCID 86655593 | — |
반응 단계
To a solution of 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (201 mg, 1.0 mmol) in THF (2 mL) was added a 20% solution of phosgene in toluene (358 μL, 1.7 mmol). The reaction was stirred at room temperature for 1 hour. The reaction was concentrated under reduced pressure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524764B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-b8798188cd69492386d462f7445ecae2 |
| 출처 메모 | uspto-grants-2013_09 |